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KMID : 0614020040190010034
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Journal of Pharmaceutical Sciences (C.N.U.)
2004 Volume.19 No. 1 p.34 ~ p.38
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Antioxidative and Acetylcholinesterase Inhibitory Activity on Spices
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Myung Pyung-Keun
Um Seon-Seob
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Abstract
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Alzheimer’s disease(AD) involves a chronic CNS inflammatory response that is associated with both head injury and beta-amyloid pathology. It was reported that the curry spice curcumin reduced oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Methanol extracts of 18 spices were screened for inhibition of acetylcholinesterase and antioxdative activity in order to evaluate the antidementia activity. The results showed that DPPH radical scavenging activity(IC_(50)) of Origanus majorana, Salvia officinalis, and Pimenta dioicallis are 161, 179, 71 (㎍/㎖) respectively and the AChE inhibitor activity(% inhibition at 1 mg/㎖) were 53.8, 60.5, 54.6 %, respectively. Bioassay-guided fractionation of Pimenta dioicallis yielded 2-methoxy-4-(2-pro-penyl)phenol and 2-methoxy-4-(1-propenyl)phenol as antioixdative constituents. It suggest that Pimenta dioicallis(allspice) is a good source of antidementia agent for AD.
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KEYWORD
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Dementia, Alzheimer’s disease, acetylcholinesterase, antioxidant, spice
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